Carnosic acid appears to alleviate adipocity-related acceleration of colon tumor formation.

PMID:  Mol Nutr Food Res. 2014 Dec ;58(12):2274-85. Epub 2014 Oct 9. PMID: 25204550 Abstract Title:  Carnosic acid suppresses colon tumor formation in association with antiadipogenic activity. Abstract:  SCOPE: This study determined the efficacy of carnosic acid (CA) for suppressing colon carcinogenesis associated with excess adiposity.METHODS AND RESULTS: Cell growth regulation by CA was evaluated in HT-29 colon adenocarcinoma cells cocultured with 3T3-L1 adipocytes. To determine the in vivo efficacies, male A/J mice were divided into four groups and fed one of the following experimental diets for 11 wk: 15% fat, 45% fat, 45% fat + 0.01% CA, or 45% fat + 0.02% CA. Azoxymethane was administered at the beginning of experimental diet and two cycles of dextran sodium sulfate were supplied 1 wk after the azoxymethane injection. The proliferation of HT-29 cells cocultured with 3T3-L1 cells was significantly higher than proliferation of control cells (p


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